| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for preparing microparticles using an emulsion process where both a solvent and a salt are used in the continuous phase of the emulsion.SOLUTION: This disclosure relates to microparticles having an angle of repose of ≤35, as measured using a Hele-Shaw cell. Specifically, this invention relates to polymer microparticles having an angle of repose of ≤35, as measured using a Hele-Shaw cell. An encapsulation method for producing the microparticles of this invention comprises: (a) forming an emulsion or double emulsion comprising a dispersed phase comprising an agent, a polymer, and a first solvent for the polymer, in a continuous process medium, where the continuous process medium comprises at least one salt and at least one second solvent, and the second solvent reduces the solubility of the first solvent in the continuous process medium; and (b) extracting the first solvent from the dispersed phase to form the microparticles. |
