SULVIVIN-DERIVED PEPTIDES AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide pharmaceutical MHC class I-restricted epitope peptides derived from tumor associated antigen sulvivin.SOLUTION: Provided is a MHC Class I-restricted epitope peptide derived from survivin, having an amino acid sequence of LPPAWQPFL and at least one of the following characteristics: (i) capable of binding to the Class I HLA molecule to which it is restricted at an affinity as measured by the amount of the peptide that is capable of half maximal recovery of the Class I HLA molecule (C50 value) which is at the most 50 μM as determined by the assembly binding assay; (ii) capable of eliciting INF-γ-producing cells in a PBL population of a cancer patient at a frequency of at least 1/10PBLs as determined by an ELISPOT assay; and/or (iii) capable of in situ detection in a tumor tissue of CTLs that are reactive with the epitope peptide.