| 摘要 |
PROBLEM TO BE SOLVED: To provide oligonucleotides capable of activating RIG-I, and eliciting anti-viral responses, particularly IFN response in cells expressing RIG-I, as well as oligonucleotides capable of activating RIG-I and suppressing a target gene.SOLUTION: Provided is an oligonucleotide having at least one blunt end comprising a double-stranded portion of at least 19 bps, preferably at least 21 bps, at least one 5' triphosphate and at least one blunt end which bears a 5'-triphosphate. The oligonucleotide is used to elicit anti-viral response, particularly, IFN response in vitro and in vivo, as well as to prevent and/or treat diseases or conditions such as infections, tumors/cancers and immune disorders. |
