CRYSTAL OF GLYCERYL PHOSPHORYL CHOLINE AND METHOD FOR PREPARING THEREOF

摘要

The present invention relates to novel crystal of glyceryl phosphoryl choline and a method for preparing the same. According to the method, the novel crystal can be obtained by adjusting crystal precipitation temperature and agitation time in a solvent environment. The method is easier than the prior method because a seeding process is not needed. The crystal is proven to have a melting point of 100°C or higher and to be a stable solid form without change over time based on result of analysis on thermal stability and polymorphism of the crystal, and thus is very useful in terms of formulation. Moreover, the crystal has: a profile of excellent moisture absorption properties as a result of moisture absorption result; proper bulk density (BD) and tap density (TD) proper to produce formulation; uniform particle distribution; and symmetrical characteristics of normalized distribution. Therefore, the crystal can be formulated in an easy manner. The crystal of glyceryl phosphoryl choline of the present invention can be used as an agent for improving brain function and an agent for treating dementia.