| 摘要 |
The invention relates to a compound of the general formula (I) or a physiologically functional derivative solvate or salt thereof (I) wherein A is a bond alkyl or alkoxy optionally substituted with one or more R' as defined herein * N(R' )CO * CON(R' ) * N(R ')CON(R' ) S SO * N(R ') * N(R ')CO * CON(R ') CO * COO * OOC * S0N(R' ) S0 or * N(R' ) SO wherein R' is as defined herein and * specifies the point of attachment to X; X is aryl cycloalkyl aralkyl heterocyclyl or heteroaryl which may be substituted with one or more R further described herein; L is a bond or * N(R)CO * CON(R) * N(R) * C=N(R) * N(R) alkyI * alkyl N(R) * N(R)CON(R) * CO * S0 alkyl * alkyl 0 alkyl * NCO CH=CH * CH=CH CONH * S0N(R) * N(R)S0 or heterocyclyl wherein * specifies the point of attachment to X; Y is H alkyl aryl aralkyl cycloalkyl heterocyclyl or heteroaryl which may be substituted with one or more R further described herein; and R and R are further described herein; as well as their use as a medicament a pharmaceutical composition comprising them a method of treatment or prevention of a medical condition entailing the administration thereof and the use thereof in the manufacture of a medicament for the treatment or prevention of a medical condition particularly autoimmune inflammatory disorders CNS disorders sleeping disorders or proliferative diseases including cancer. The invention further relates to a specific process for the preparation of said compounds. |
