APTAMERS TO TISSUE FACTOR PATHWAY INHIBITORS AND THEIR USE AS BLEEDING DISORDER THERAPEUTICS

摘要

The invention relates gener¬ally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diag¬nostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI ap¬tamers may be used before, during and/or af¬ter medical procedures to reduce complica¬tions or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.