TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS

摘要

A composition comprising: a water insoluble nanoparticle to which is adhered at least one alpha-hydroxy phosphonate moiety having the formula: wherein S is a spacer, L is a linkage between S and R and R is a polymeric hydrophilic moiety and m and p are 1-5 and n and o are 0-5.