USE OF ANOCTAMIN AS A BIOMARKER FOR RADIATION BIODOSIMETRY

摘要

In one embodiment, the present invention pertains to the use of anoctamin as a biomarker for determining radiation dosimetery. In certain embodiments, the present invention relates to the use of anoctamin as a biomarker for diagnosing the presence of radiation toxicity in a subject who has been exposed to ionizing radiation, as well as for determining the absorbed radiation dose in a subject who has been exposed to a known or unknown dose of ionizing radiation. In another embodiment, the expression level of anoctamin can be used as a secondary endpoint to determine mechanisms of action and/or pharmacodynamic (PD) effects of an agent for reducing radiation toxicity.

主权项

1. A method for determining radiation dose absorbed by a subject who has been, or is suspected of having been, exposed to ionizing radiation, wherein the method comprises:
(a) providing a biological sample from a subject who has been, or is suspected of having been, exposed to ionizing radiation; (b) determining expression level of anoctamin 1 in the subject's biological sample; and (c) determining the radiation dose absorbed by the subject based on the level of expression determined in step (b).