| 发明名称 |
WATER SOLUBLE 4-AZAPODOPHYLLOTOXIN ANALOGS |
| 摘要 |
The present invention relates to 4-azapodophyllotoxin analogs of formula (I) in which X, R1, R2, R3, R4 and Ar are as defined in claim 1, preferably a pharmaceutically acceptable salt thereof, optionally in the form of a solvate, a composition comprising said analogs, their use as medicament, in particular for the treatment of cancer, and a process for their preparation. |
| 申请公布号 |
CA2936874(A1) |
申请公布日期 |
2015.07.23 |
| 申请号 |
CA20152936874 |
申请日期 |
2015.01.15 |
| 申请人 |
UNIVERSITE PARIS DESCARTES;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
CHABOT, GUY;GIORGI-RENAULT, SYLVIANE;DESBENE-FINCK, STEPHANIE;HELISSEY, PHILIPPE;LABRUERE, RAPHAEL;TESTUD, MARLENE;SCHERMAN, DANIEL |
| 分类号 |
C07D219/10;A61K31/473;A61K31/4741;A61P35/00;C07D491/056 |
主分类号 |
C07D219/10 |
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