| 发明名称 |
COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE |
| 摘要 |
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is their use in the treatment of diseases such as diabetes, Alzheimer's, Parkinson's, hemophilia, lysosomal storage diseases and cancer. |
| 申请公布号 |
US2015203477(A1) |
申请公布日期 |
2015.07.23 |
| 申请号 |
US201314408736 |
申请日期 |
2013.06.18 |
| 申请人 |
University of Kansas ;The Regents of the University of Michigan ;Wayne State University ;Sanford-Burnham Medical Research Institute |
发明人 |
Golden Jennifer E.;Aube Jeffrey;Flaherty Daniel P.;Fribley Andrew M.;Kaufman Randal J.;Chung Thomas D.Y.;Pinkerton Anthony B.;Hedrick Michael Pablo |
| 分类号 |
C07D405/12;C07C303/36;A61K45/06;A61K31/5377;A61K31/496;C07D307/71;A61K31/4525 |
主分类号 |
C07D405/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A selective activator of the apoptotic arm of the Unfolded Protein Response, wherein said activator has the structure of Formula I, or a pharmaceutically acceptable salt, ester or prodrug thereof,wherein
X is C; R1 is a hydrogen; and R2 is a substituted alkyl group. |
| 地址 |
Lawrence KS US |
