发明名称 |
Topical Drug Delivery System for Ophthalmic Use |
摘要 |
Topical drug delivery systems for ophthalmic use including mixed nanomicellar formulations of water-insoluble drugs and methods of treating diseases affecting the posterior ocular segments are disclosed. In an embodiment, an aqueous ophthalmic solution includes nanomicelles in a physiologically acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration from about 0.01% w/v to about 1.00% w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of hydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at a concentration ranging from about 3.0% w/v to about 5.0% w/v stabilized with octoxynol-40 at a concentration ranging from about 1.0% w/v to about 3.0% w/v. |
申请公布号 |
US2015202150(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
US201514676993 |
申请日期 |
2015.04.02 |
申请人 |
Aurinia Pharmaceuticals Inc. |
发明人 |
Mitra Ashim K.;Velagaleti Poonam R.;Grau Ulrich M. |
分类号 |
A61K9/107;A61K47/10;A61K47/22;A61K31/573;A61K9/00 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
1. An aqueous ophthalmic solution comprising nanomicelles in a physiologically acceptable buffer, having a pH of 5.0 to 8.0, wherein a corticosteroid at a concentration ranging from about 0.01% w/v to about 1.00% w/v is solubilized through entrapment in a mixed micellar hydrophobic core with a corona composed of hydrophilic chains extending from the hydrophobic core, wherein the nanomicelles comprise vitamin E TPGS at a concentration ranging from about 2.0% w/v to about 5.0% w/v stabilized with octoxynol-40 at a concentration ranging from about 1.0% w/v to about 3.0% w/v. |
地址 |
Victoria CA |