| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxoisoindolines, and a method of reducing TNF-αlevels.SOLUTION: Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF-αin a mammal. Specific embodiments include 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1,3-dioxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4-aminoisoindoline.</p> |
