发明名称 |
ANTI-ANGIOGENIC COMPOUNDS |
摘要 |
Compounds of the formula A-X-Y-B and compositions are described which are useful especially for treatment of angiogenesis-related diseases or disorders such as neovascularisation of the eye, age- related macular degeneration, diabetic retinopathy or cancer, wherein A is a six membered heteroaryl ring containing 2 nitrogen atoms which is optionally substituted with R1; R1 is H, CI-6 alkyl, CN, CONR2R3; R2 and R3 which may be the same or different and selected from H, CI-6 alkyl or R2 and R3 form a ring; the group X-Y is an alkyne or alkene, in the case wherein X-Y is an alkene the double bond may be cis or trans and optionally substituted with R1 B is an aryl; or five or six membered heteroaryl ring containing 1 to 3 heteroatoms, both of which may optionally substituted with one or more R4; R4 is R1 or OR5; R5 is H, COR6 or R6; and R6 is CI-6 alkyl and salts thereof. |
申请公布号 |
WO2015107122(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
WO2015EP50710 |
申请日期 |
2015.01.15 |
申请人 |
UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND, DUBLIN;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN |
发明人 |
KENNEDY, BREANDAN;REYNOLDS, ALISON;O'SULLIVAN, JACINTHA;BAXTER, ANDREW, DOUGLAS |
分类号 |
C07D233/20;A61K31/4164;A61K31/4965;A61K31/505;A61P27/02;A61P35/00;C07D239/26;C07D241/12;C07D401/06 |
主分类号 |
C07D233/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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