| 发明名称 |
PERFORIN 2 DEFENSE AGAINST INVASIVE AND MULTIDRUG RESISTANT PATHOGENS |
| 摘要 |
Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. avium, Salmonellae, MRSA (drug resistant Stapholococci), E coli. Compounds identified by screening assays are selected based on the effects of these compounds on P2. Use of these compounds in the treatment of infectious diseases, in particular, bacteria and antibiotic-resistant bacteria is also provided. |
| 申请公布号 |
US2015204845(A1) |
申请公布日期 |
2015.07.23 |
| 申请号 |
US201314396473 |
申请日期 |
2013.03.15 |
| 申请人 |
University of Miami |
发明人 |
De Armas Lesley;Lyapichev Kirill;McCormack Ryan;Podack Eckhard |
| 分类号 |
G01N33/50;A61K33/00;A61K38/02;A61K31/7088 |
主分类号 |
G01N33/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of modulating function, activity or expression of Perforin-2 (P2) comprising: administering to a patient, an effective amount of at least one agent which modulates the function, activity or expression of one or more molecules associated with P2 expression, function or activity; and, modulating the function or expression of P2. |
| 地址 |
Miami FL US |
