| 发明名称 |
MONOCLONAL ANTIBODY AGAINST HUMAN MIDKINE |
| 摘要 |
A monoclonal antibody, which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine, has been found to have excellent reactivity with and excellent neutralizing activity against human midkine. Moreover, the activity of suppressing the proliferation of tumor has been observed in the antibody having excellent neutralizing activity. The use of the antibody of the present invention makes it possible to treat cancer effectively and to detect or purify midkine efficiently. |
| 申请公布号 |
US2015203573(A1) |
申请公布日期 |
2015.07.23 |
| 申请号 |
US201314417980 |
申请日期 |
2013.07.30 |
| 申请人 |
NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY ;MEDICAL & BIOLOGICAL LABORATORIES CO., LTD. |
发明人 |
Kadomatsu Kenji;Kishida Satoshi;Ono Kenichiro;Yagi Kasumi |
| 分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A monoclonal antibody which recognizes at least two amino acids among amino acids located at position 69, position 79, position 81 and position 102 of human midkine and which has neutralizing activity against human midkine. |
| 地址 |
Nagoya-shi, Aichi JP |
