PROCESS FOR THE PREPARATION OF INTERMEDIATES FOR THE SYNTHESIS OF DABIGATRAN ETEXILATE, AND CRYSTALLINE FORMS OF SAID INTERMEDIATES

摘要

The present invention relates to new processes for the preparation of synthesis intermediate products useful in the preparation of Dabigatran Etexilate on an industrial scale. The invention also relates to new crystalline forms of intermediate products thus obtained.

主权项

1. Process for the preparation of the hydrochloride salt of the compound of formula (IV-HCl) characterized in that the compound of formula (III) in free base form is reacted with hydrogen chloride in the presence of an alcohol, and then with ammonia in an aqueous medium to form the amidine hydrochloride salt of formula (IV-HCl) in the presence of water.