Biomarkers For Diagnosis Of Diabetes And Monitoring Of Anti-Diabetic Therapy

摘要

The present invention relates to the use of N-linked glycan profiles of blood or blood component proteins as biomarkers for diagnosing diabetes mellitus and for monitoring the efficacy of anti-diabetic therapy. Specifically, the present invention relates to detecting changes in the amounts of N-linked glycans as diagnostic biomarkers for diabetes mellitus and as indicators of the efficacy of anti-diabetic therapy over time.

主权项

1. A method of monitoring a level of glycemic control in a subject during anti-diabetic therapy or treatment comprising:
(a) providing an N-glycan composition of a blood or blood component sample obtained from the subject at a first time-point during the anti-diabetic therapy or treatment; and (b) determining an N-glycan composition of a blood or blood component sample obtained from the subject at a second time-point during the anti-diabetic therapy or treatment, wherein the second time-point is subsequent to the first time-point, wherein a difference between the N-glycan composition of the sample at the second time-point and the N-glycan composition of the sample at the first time-point indicates an increased or decreased level of glycemic control at the second time-point compared to the first time-point.