TREATMENT OF SPINAL CORD INJURY OR TRAUMATIC BRAIN INJURY BY INHIBITION OF AMYLOIDOGENIC PROTEINS AND SYNUCLEIN PROTEIN ACCUMULATION OR AGGREGATION

摘要

Methods for the treatment of spinal cord injury or traumatic brain injury are provided. In certain embodiments, the methods include the use of a molecular tweezers and/or nucleobase oligomer capable of inhibiting the accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins. Examples of treatments that may inhibit accumulation or aggregation of one or more amyloidogenic proteins and/or synuclein proteins include treatment with a synuclein antisense nucleobase oligomer or treatment with the molecular tweezers CLR01. These treatments may improve outcomes of spinal cord surgery or traumatic brain injury, including, without limitation, neuronal survival, neuronal regeneration, and recovery of neuronal functions.

主权项

1. A method of treating a subject having a spinal cord injury or traumatic brain injury, said method comprising administering to said subject a molecular tweezers that inhibits and/or modulates aggregation of an amyloidogenic protein or a synuclein protein in an amount sufficient to reduce aggregation and/or cytotoxicity of said amyloidogenic protein.