发明名称 |
A TUMOR DECONSTRUCTION PLATFORM FOR THE ANALYSIS OF INTRA-TUMOR HETEROGENEITY |
摘要 |
The present invention provides a method for concurrent resolution of the cancer stem cell (CSC) derived hierarchy, genetic instability, differentially cycling cells and host cells recruited for performing tumor growth supporting functions; and (ii) quantification, monitoring and analysis of these populations. The first level of analysis can be carried out using either CSC- and progenitor-specific markers or a marker-free approach based on label-chase to resolve the tumor regenerative hierarchy. The next level involves combinatorial quantification of differential DNA- RNA contents to identify recruited host and tumor cell variants resulted from genetic instability and differential cycling within the tumor. |
申请公布号 |
WO2015107499(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
WO2015IB50358 |
申请日期 |
2015.01.17 |
申请人 |
NATIONAL CENTRE FOR CELL SCIENCE |
发明人 |
BAPAT, SHARMILA, A.;NAIK, RUTIKA., R. |
分类号 |
G01N33/53;C12Q1/24;G01N1/30 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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