INHIBITORS OF PHOSPHODIESTERASE 10 ENZYME

摘要

The present invention relates to novel imidazo[1,2-b]pyridazine and imidazo[1,2-a]-pyrazine derivatives which are inhibitors of the phosphodiesterase 10 enzyme (PDE10) and which may be useful for the treatment or prevention of neurological, psychiatric and metabolic disorders in which the PDE10 enzyme is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, to the use of such compounds or pharmaceutical compositions for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases.

主权项

1. A compound of Formula (I)or a stereoisomeric form thereof, wherein
R1 is H and R2 isor wherein R1 and R2, taken together with the carbon atom to which they are attached, form a radical of Formulaand
the bicycleis a bicycle of Formula a)or a bicycle of Formula b)or a pharmaceutically acceptable salt or a solvate thereof.