IRON GARNET NANOPARTICLES FOR CANCER RADIOTHERAPY AND CHEMOTHERAPY

摘要

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165(165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particle and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandages coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).

主权项

1. A iron garnet nanoparticle or iron garnet particle comprising one, or any combination of, activatable nuclide selected from lanthanum-139, praseodymium-141, samarium-152, dysprosium-164, holmium-165, rhenium-185 and or rhenium-187 and, optionally, comprising a radiosensitizer.