| 发明名称 |
NOVEL ANTI- ALPHA5 BETA1 ANTIBODIES AND USES THEREOF |
| 摘要 |
The present invention provides new anti-α5β1 antibodies, compositions and kits comprising the antibodies, and methods of making and using the antibodies. |
| 申请公布号 |
US2015203581(A1) |
申请公布日期 |
2015.07.23 |
| 申请号 |
US201514593950 |
申请日期 |
2015.01.09 |
| 申请人 |
GENENTECH, INC. |
发明人 |
LIANG Wei-Ching;PLOWMAN Gregory D.;WU Yan;YE Weilan |
| 分类号 |
C07K16/28;C07K16/22;A61K47/48 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An anti-β5β1 antibody comprising(SEQ ID NO: 15)a VL domain comprising a CDR-L1 comprising TL-S/T-S/P/T-Q/N-H-F/S-T/I-Y-K/T-I-G/D/S;(SEQ ID NO: 16)a CDR-L2 comprising L/I-N/T-S-D/H/S-G/S-S/L/T-H/Y-N/K/Q/I-K/T-G/A-D/S/V;(SEQ ID NO: 17)a CDR-L3 comprising G/A-S/A/Y-S/Y-Y-S/A/Y-S/Y/T-GY-V/I;and(SEQ ID NO: 18)a VH domain comprising a CDR-H1 comprising GFTFS-N/A-RW-I/V-Y;(SEQ ID NO: 19)a CDR-H2 comprising GIKTKP-N/A/T-I/R-YAT-E/Q-YADSVKG;and(SEQ ID NO: 20)a CDR-H3 comprising L/V-TG-M/K-R/K-YFDY. |
| 地址 |
South San Francisco CA US |
