| 主权项 |
1. A compound represented by formula (I):or a pharmaceutically acceptable salt thereof, wherein:
X is O, S(O)r, NR12, C(O) or CH2, wherein r is 0, 1, or 2; A1, A2, and A7 are each independently CR2 or N; A3, A5, and A6 are each independently CR2, C(R2)2, N, or NR19, wherein at least three of A1, A2, A3, A5, A6, and A7 are CR2 or C(R2)2; “------” indicates a double or a single bond; R1 is a C6-20alkyl, a C3-14carbocyclyl, a 3- to 15-membered heterocyclyl, a C6-10aryl, or a five- to 14-membered heteroaryl, wherein R1 may be optionally substituted with from one to six independently selected R6; R2, for each occurrence, is independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, cyano, carboxy, C1-6alkyl, C1-6haloalkyl, C3-8cycloalkyl, C3-8halocycloalkyl, C1-6alkoxy, C1-6haloalkoxy, C3-8cycloalkoxy, C3-8halocycloalkoxy, C1-6alkanoyl, amino, N—(C1-6alkyl)amino, N,N-di-(C1-6alkyl)amino, C1-6alkoxycarbonyl, C1-6alkanoyloxy, carbamoyl, N—(C1-6 alkyl)carbamoyl, N,N-di-(C1-6 alkyl)carbamoyl, C1-6alkylamido, mercapto, C1-6alkylthio, C1-6alkylsulfonyl, sulfamoyl, N—(C1-6alkyl)sulfamoyl, N,N-di-(C1-6alkyl)sulfamoyl, and C1-6alkylsulfonamido; each R3 and each R4 are each independently hydrogen, a carboxy, C1-6alkyl, or a C2-6alkenyl; or R3 and R4 together with the carbon to which they are attached are —C(═O)—, a C3-8spirocycloalkyl, or a 3- to 8-membered spiroheterocycloalkyl; B is a fused ring system, a bridged ring system, a spiro ring system, or a combination thereof; or B is a bicyclic ring system represented by the following formula:wherein B′ and B″ are each independently selected from the group consisting of monocyclic C3-8carbocyclyl, a monocyclic 3- to 8-membered heterocyclyl, phenyl, or a 5- to 6-membered heteroaryl, wherein the heterocyclyl and the heteroaryl comprises 1 to 3 heteroatoms independently selected from N, S, or O; provided that when B is a fused ring system it is not 1H-benzo[d][1,2,3]triazole;
R5, for each occurrence, is independently hydroxyl, halo, C1-6alkyl, or —(CR17R18)p—R7; or two R5 on the same carbon atom may be ═O; R6, for each occurrence, is independently selected from the group consisting of halo, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C3-8cycloalkyl, C6-10aryl, C1-6alkoxy-C1-6alkyl, and tri-(C1-6alkyl)silyl; or two R6 that are attached to the same carbon atom may form C3-8spirocycloalkyl or 3- to 8-membered spiroheterocycloalkyl; R7 is —OH, —C(O)OR15, —C(O)N(R16)2, —C(O)N(R15)—S(O)2R15, —S(O)2OR15, —C(O)NHC(O)R15, —Si(O)OH, —B(OH)2, —N(R15)S(O)2R15, —S(O)2N(R15)2, —O—P(O)(OR15)2, —P(O)(OR15)2, —CN, —S(O)2NHC(O)R15, —C(O)NHS(O)2R15, —C(O)NHOH, —C(O)NHCN, —N(R20)2, or a heteroaryl or a heterocyclyl selected from the group consisting of formulae (a)-(i′): R8, R12, R19, and R20 are each independently hydrogen or a C1-6alkyl; R15 for each occurrence is independently selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C3-8cycloalkenyl, C6-10aryl, a 5 to 14 membered heteroaryl, and a 3 to 15 membered heterocyclyl; wherein the heteroaryl or heterocyclyl comprises from 1 to 10 heteroatoms independently selected from O, N, or S; and wherein R15 may be optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, C1-4alkoxy, C1-4alkyl, cyano, nitro, hydroxyl, amino, N—(C1-4alkyl)amino, N,N-di-(C1-4alkyl)amino, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N-di-(C1-4alkyl)carbamoyl, C1-4alkylamido, C1-4alkylsulfonyl, C1-4alkylsulfonamido, sulfamoyl, N—(C1-4alkyl)sulfamoyl, and N,N—(C1-4dialkyl)-sulfamoyl; R16 is R15; or two R16 together with the nitrogen atom to which they are attached form a 5 to 14 membered heteroaryl or a 3 to 15 membered heterocyclyl, wherein the heteroaryl or heterocyclyl comprises from 1 to 10 heteroatoms independently selected from O, N, or S; and wherein the heteroaryl or heterocyclyl may be optionally substituted with from 1 to 3 substituents independently selected from the group consisting of halo, C1-4alkoxy, C1-4alkyl, cyano, nitro, hydroxyl, amino, N—(C1-4alkyl)amino, N,N-di-(C1-4alkyl)amino, carbamoyl, N—(C1-4alkyl)carbamoyl, N,N-di-(C1-4alkyl)carbamoyl, C1-4alkylamido, C1-4alkylsulfonyl, C1-4alkylsulfonamido, sulfamoyl, N—C1-4alkylsulfamoyl, and N,N—(C1-4dialkyl)-sulfamoyl; R17 and R18, for each occurrence, are each independently hydrogen, a halo, or a C1-4haloalkyl; Rc is hydrogen or a C1-4alkyl; i is an integer from 0 to 6; n is an integer from 1 to 6; m is 0 or 1, provided that when m is 0, B comprises at least one nitrogen; p is 0 or an integer from 1 to 6; q is 0, 1, 2, 3, or 4; provided that the compound is not 2-((6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)methyl)octahydrocyclopenta[c]pyrrole-3a-carboxylic acid or 6-phenoxy-2-(2-(4-phenylpiperidin-1-yl)ethyl)-1,2,3,4-tetrahydronaphthalen-1-ol. |
