发明名称 |
Solid Forms of (R)-1(2,2-Difluorobenzo[D][1,3]Dioxol-5-yl)-N-(1-(2,3-Dihydroxypropyl)-6-Fluoro-2-(1-Hydroxy-2-Methylpropan-2-yl)-1H-Indol-5-yl)Cyclopropanecarboxamide |
摘要 |
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith. |
申请公布号 |
US2015203478(A1) |
申请公布日期 |
2015.07.23 |
申请号 |
US201514676205 |
申请日期 |
2015.04.01 |
申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Keshavarz-Shokri Ali;Zhang Beili;Alcacio Tim Edward;Lee Elaine Chungmin;Zhang Yuegang;Krawiec Mariusz |
分类号 |
C07D405/12;A61K45/06;A61K31/404 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
1. (R)-1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide characterized as crystalline Form A. |
地址 |
Boston MA US |