| 摘要 |
The invention pertains to an encapsulation system; in particular a 3-phase system comprising an inner, second and outer phase wherein the second phase is gaseous, and wherein the 3-phase system has a lifetime of at least 3 min and the second phase has a diameter of less than 1 mm. An example of such a system is a stable, small antibubble. Also, the invention pertains to methods of making such 3-phase systems, and to use and methods of use thereof. In particular, 3-phase systems according to the invention are stabilized by surface active particles or molecules, such as for instance colloidal particles. The 3-phase systems of the invention can include a variety of other compounds, and can among others be used in pharmaceutical- or food-based applications. In particular, a 3-phase system according to the invention, such as for example an antibubble, may deliver pharmaceutical compounds. |
| 主权项 |
1. Method of producing a 3-phase system comprising an inner, second and outer phase, preferably wherein the outer phase is aqueous, comprising
making a 2-phase system comprising a dispersed and a continuous phase in which the continuous phase is a volatile compound, preferably a volatile organic liquid. dispersing said 2-phase system in a third phase to obtain a ternary mixture, and removing or evaporating the volatile compound so that the second phase becomes gaseous, preferably wherein removing or evaporating the volatile compound is achieved by freeze-drying, wherein the 3-phase system is stabilized by surface-active colloidal particles. |
