| 摘要 |
The present invention provides novel compounds and pharmaceutical compositions suitable for administration to mammals, for the prevention and/or treatment of cancer, precancerous conditions, pain, fever, skin disorders, inflammation-related diseases and/or cardiovascular diseases. The compounds of the invention have improved efficacy and safety, including higher potency and/or fewer or less severe side effects, than conventional therapies. These comprise a biologically active moiety or portion (A) preferably derived from a non-steroidal anti-inflammatory drug or NSAID (A), bound via a linker moiety (B) to functional moiety Z, which facilitates access of the compound into cells. The moiety Z can comprise, for example, a phosphorous-containing group, a nitrogen-containing group, or a folic acid residue. |
