CONTROLLED-RELEASE NANOPARTICULATE COMPOSITIONS

摘要

PROBLEM TO BE SOLVED: To provide controlled release nanoparticulate compositions comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration.SOLUTION: A controlled release nanoparticulate composition comprises (a) a poorly soluble agent to be administered having an effective average particle size of less than about 1000 nm; (b) at least one surface stabilizer associated with the surface of the agent, and (c) at least one pharmaceutically acceptable rate-controlling polymer. The composition provides controlled release of the agent for a time period ranging from about 2 to about 24 hours or longer.