METHODS AND SYSTEMS FOR ANALYSIS

摘要

Provided herein are systems and methods for the detection, quantification, and/or monitoring of analytes in samples. The systems and methods can be used, for example, to track the deposition and electrochemical behavior of individual nanoparticles and nanoparticles clusters clusters in situ with high spatial and temporal resolution. The systems and methods can be used to track the deposition and oxidation of several hundreds to thousands of nanoparticles simultaneously and reconstruct their voltammetric curves at the single nanoparticle level.

主权项

1. A system, comprising:
a) an electrochemical cell comprising
i) a working electrode in electrochemical contact with a liquid sample comprising an analyte;ii) a sample containment vessel comprising a top end, a bottom end, an exterior surface, and an interior void defined by an interior surface;
wherein the bottom end forms a liquid tight seal with the working electrode;wherein the liquid sample is contained in the volume defined by the interior void of the sample containment vessel and the working electrode;iii) one or more additional electrodes in electrochemical contact with the liquid sample; andiv) a power supply electrically coupled to the working electrode and the one or more additional electrodes; b) a light source configured to illuminate the liquid sample; and c) an instrument configured to capture an optical signal from the liquid sample.