INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
摘要
This invention relates to compounds of Formula I having the following general structure: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
申请公布号
EP2773206(A4)
申请公布日期
2015.07.22
申请号
EP20120845426
申请日期
2012.10.25
申请人
MERCK SHARP & DOHME CORP.
发明人
WALSH, SHAWN, P.;PASTERNAK, ALEXANDER;SHI, ZHI-CAI;CATO, BRIAN