フルオロ置換３，５−ジシアノ−４−（１Ｈ−インダゾール−５−イル）−２，６−ジメチル−１，４−ジヒドロピリジン誘導体およびそれらの使用方法

摘要

The present invention relates to novel fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihy-dropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions, particularly cancer and other proliferative disorders.