| 摘要 |
<p>A solution for protecting, storing and perfusing organs during transplantation and other surgical procedures containing osmolytes and oncolytes, electrolytes, substances with antioxidant activity, cryoprotectants, cytoskeleton stabilizers, precursors for the synthesis of high-energy adenylates, apoptosis inhibitors, and a stimulator of endothelial cell regeneration. A solution according to the present invention contains: trehalose at a concentration from 1 m M to 50 m M, inosine at a concentration from 0.1 mM to 5 mM,α-ketobutyric acid or its salts at a concentration from 0.1 mM to 25 m M, aurintricarboxylic acid or its salts at concentrations from 0.01 m M to 1 m M and N-methylnicotinamide at a concentration from 0.1 mM to 5 m M. The scope of uses of said solution encompasses perfusion and storage at low temperature of organs collected from a donor or one subjected to a surgical procedure.</p> |
