| 发明名称 |
MULTIFUNCTIONAL ORAL VACCINE BASED ON CHROMOSOME RECOMBINEERING |
| 摘要 |
A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein. |
| 申请公布号 |
EP2895596(A1) |
申请公布日期 |
2015.07.22 |
| 申请号 |
EP20130836396 |
申请日期 |
2013.09.16 |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES |
发明人 |
DHARMASENA, MADUSHINI NIROSHA;KOPECKO, DENNIS J. |
| 分类号 |
C12N1/21;A61K35/74;A61P31/04;C12N15/31 |
主分类号 |
C12N1/21 |
| 代理机构 |
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