| 主权项 |
1. A compound of Formula Va: or a pharmaceutically acceptable salt, hydrate, solvate, enantiomer, or stereoisomer thereof; wherein: F is a heteroaryl selected from pyridine, pyrazine, pyridazine, pyrimidine, 1,2,4-triazine or 1,3,5-triazine, optionally substituted with halogen, hydroxyl group, —CF3 group, C1-C6 alkoxy group, C1-C6 straight chain alkyl, C3-C6 branched chain alkyl or C3-C6 cycloalkyl group, wherein the number of substituents does not exceed the number of available C—H bonds of the heteroaryl; with multiple substitutions, each substituent on the heteroaryl is independent of the other substituents; m is an integer ranging from 0 to 3; p is an integer ranging from 1 to 5; H is selected from —S(O)n-(CH2)q-, —O—(CH2)q-, or —C(O)—(CH2)q-; n is an integer ranging from 0 to 2; q is an integer ranging from 0 to 5; K is selected from (i) C3-C7 cycloalkyl optionally substituted with two or more of R14, R15, and R16, (ii) C1-C6 straight or branched alkyl optionally substitiuted with one or more of R14, R15 and R16, and (iii) R13 is selected from H, C1-C6 straight chain alkyl, C3-C6 branched chain alkyl or C3-C6 cycloalkyl; R20 is selected from H, —CF3, C1-C6 straight chain alkyl, C3-C6 branched chain alkyl or C3-C6 cycloalkyl; R14, R15 and R16 can independently be H, C1-C6 straight chain alkyl, C3-C6 branched chain alkyl, C1-C6 hydroxyalkyl, C1-C6 alkoxy, alkoxyalkyl in which the alkoxy and alkyl portions each independently contain from 1 to 6 carbon atoms, alkoxyalkoxy in which the alkoxy portions each independently contain from 1 to 6 carbon atoms, halogen, —OH, —NH2, —CF3, C1-C6 monoalkylamino, C1-C6 dialkylamino, and nitrogen containing heterocycles optionally substituted with one or more of R17 and R18; or wherein X can be a bond, O, S or NR19; R17, R18 and R19 are independently selected from H, C1-C6 straight chain alkyl, C3-C6 branched chain alkyl, C3-C6 cycloalkyl, C1-C6 hydroxyalkyl, alkoxyalkyl in which the alkoxy and alkyl portions each independently contain from 1 to 6 carbon atoms, —CF3, or —C(O)O—, or R17 and R18 can be taken together to form a 4 to 7 membered monocycloalkyl ring or 8-14 bicycloalkyl ring, each optionally containing between 1-3 heteroatoms selected from N, O or S, or; r is an integer ranging from 0 to 3; t is an integer ranging from 1 to 2; and u is an integer ranging from 1 to 6. |
