| 发明名称 | Toll-like receptor 5 ligands and methods of use | ||
| 摘要 | The invention provides methods to elicit an immune response with an immunomodulatory flagellin polypeptide having toll-like receptor 5 (TLR5) binding, and further comprising an ADCC targeting molecule. | ||
| 申请公布号 | US9085616(B2) | 申请公布日期 | 2015.07.21 |
| 申请号 | US201113191093 | 申请日期 | 2011.07.26 |
| 申请人 | THE UNIVERSITY FOR SYSTEMS BIOLOGY;UNIVERSITY OF WASHINGTON | 发明人 | Aderem Alan;Hayashi Fumitaka;Smith Kelly D.;Underhill David M.;Ozinsky Adrian |
| 分类号 | A61K39/39;C07K14/21;C07K14/195;C07K14/24;C07K14/255;A61P31/04;C07K14/25;C07K14/20;C07K14/32;C07K14/33;A61K39/02;A61P37/04;C07K14/28;C07K14/245;A61K39/00 | 主分类号 | A61K39/39 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method to stimulate a TLRS-mediated enhancement of an antigen specific immune response in subject which method comprises administering to said subject said antigen along with a flagellin polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:11-SEQ ID NO:34, and wherein said flagellin polypeptide does not contain said antigen. | ||
| 地址 | Seattle WA US | ||