Histone demethylase inhibitors

摘要

The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.

主权项

1. A method of inhibiting a histone demethylase enzyme comprising contacting the histone demethylase enzyme with a compound of Formula (XI): wherein: Q is —CO2R, —C(O)N(H)CN, —C(O)N(H)OH, or tetrazolyl; R is hydrogen or optionally substituted alkyl; G is —X—Y;
X is —C1 alkylene; andY is optionally substituted tetralinyl, optionally substituted tetrahydroquinolinyl, substituted pyridyl, optionally substituted naphthyl, optionally substituted indolyl, optionally substituted benzofuranyl, optionally substituted adamantyl, or optionally substituted indanyl.