Hemoglobin A1c-specific aptamer, hemoglobin-specific aptamer, and applications thereof

摘要

The present invention provides a Hemoglobin A1c-specific aptamer and a Hemoglobin-specific aptamer. The aptamers were selected in vitro using SELEX and a microfluidic chip system. The aptamers established low free energy, thus were more stable than conventional antibodies. The high specificity of the aptamers to Hemoglobin A1c or Hemoglobin allows them to be effectively used in diagnosis of diabetes and/or anemia.

主权项

1. An aptamer that specifically binds to hemoglobin A1c, wherein the aptamer is a nucleic acid molecule consisting essentially of:
the nucleic acid sequence of SEQ ID NO: 1.