Process for preparing fesoterodine

摘要

The present invention relates to an improved process for the preparation of Fesoterodine and pharmaceutically acceptable salts thereof. The present invention particularly relates to a process for the preparation of fesoterodine and pharmaceutically acceptable salts thereof which involves use and preparation of R(+)benzyl tolterodine and fumarate salt of R(+)-[4-benzyloxy-3-(3-diisopropylamino-1-phenylpropyl)-phenyl]-methanol.

主权项

1. A process for preparing Fesoterodine or its enantiomer, or a salt thereof, comprising:
obtaining a compound of formula IV(a) or formula IV(b) or a salt there of,wherein Bn is benzyl group, by the resolution of the corresponding racemic compound of formula (III):wherein resolution of racemic compound of formula (III) through formation of the diastereomeric salt thereof with an optically active acid; andpreparing Fesoterodine or its enantiomer from compounds IV(a) or IV(b) or a salt thereof.