发明名称 |
<i>H. pylori </i>lipopolysaccharide outer core epitope |
摘要 |
Helicobacter pylori, one of the most common human pathogens, is associated with the development of human chronic gastritis, peptic ulcers and gastric cancer. The invention relates to a α1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula (I): wherein R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan linked to an α1,3-DD-heptan, and wherein the last DD-Hep residue of α1,3-DD-heptan is capped with β-GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.; |
申请公布号 |
US9085610(B2) |
申请公布日期 |
2015.07.21 |
申请号 |
US201013321881 |
申请日期 |
2010.07.30 |
申请人 |
National Research Council of Canada |
发明人 |
Altman Eleonora;Harrison Blair A.;Chandan Vandana |
分类号 |
A61K39/02;A61K47/48;A61K39/00;C08B5/00;C07K16/12;C08B37/00;C08L5/00 |
主分类号 |
A61K39/02 |
代理机构 |
Ade & Company Inc. |
代理人 |
Williams Michael R.;Ade & Company Inc. |
主权项 |
1. A composition comprising an effective amount of a purified α1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula I: wherein the R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan comprising from 4 to 12 α1,6-linked glucose residues linked to an α1,3-DD-heptan, wherein the last DD-Hep residue of the α1,3-DD-heptan is capped with β-GlcNAc residue and an effective amount of an adjuvant. |
地址 |
Ottawa, Ontario unknown |