| 发明名称 |
Antigen binding proteins |
| 摘要 |
The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3. |
| 申请公布号 |
US9085622(B2) |
申请公布日期 |
2015.07.21 |
| 申请号 |
US201113639918 |
申请日期 |
2011.09.02 |
| 申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED |
发明人 |
Clarke Neil James;Johanson Kyung Oh;Jonak Zdenka Ludmila;Taylor Alexander H.;Hopson Christopher B.;Trulli Stephen H.;Haskova Zdenka;Lee Judithann M.;White John R.;Xue Yu |
| 分类号 |
C07K16/28;A61K39/395;C07K16/32;A61K39/00 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
Long William Peter;Han William T. |
| 主权项 |
1. An anti-HER3 antibody comprising a heavy chain variable region having the CDRH1 amino acid sequence shown in SEQ ID NO: 31, the CDRH2 amino acid sequence shown in SEQ ID NO: 32, and the CDRH3 amino acid sequence shown in SEQ ID NO: 33; and a light chain variable region having the CDRL1 amino acid sequence shown in SEQ ID NO: 35, the CDRL2 amino acid sequence shown in SEQ ID NO: 36, and the CDRL3 amino acid sequence shown in SEQ ID NO: 37. |
| 地址 |
GB |
