Preparation in film form for biphasic release of pharmacologically active or other substances

摘要

A polymer-based preparation in film form for biphasic release of substances present therein to liquid surroundings, is characterized in that the preparation comprises at least two polymer matrix layers which differ in terms of their construction from polymers, with release taking place rapidly from one of the layers, and release taking place slowly from at least one other layer.

主权项

1. A polymer preparation in film form comprising:
at least two polymer matrix layers; wherein said at least two polymer matrix layers comprise:
an initial layer; anda second layer; andoptionally following layers;said initial layer, said second layer, and said optional following layers each containing a substance to be released; wherein said initial layer, said second layer, and said optional following layers differ in their polymer composition, with release taking place rapidly from one of the polymer matrix layers, and release taking place slowly from at least one other of the polymer matrix layers; wherein the second layer contacts the initial layer; wherein said matrix of the rapidly releasing layer comprises:
a polyvinyl alcohol or a polyvinyl alcohol-containing polymer mixture; andan amount of said substance to be released; wherein said matrix of each slowly releasing layer comprises:
at least one polymer selected from the group consisting of polyurethane, polyvinyl acetate, and copolymers thereof; andan amount of said substance to be released; and wherein said polymer preparation is in film form and provides biphasic release of substances contained therein to liquid surroundings.