4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases

摘要

The present application relates to novel dipyridyl-dihydropyrazolones, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.

主权项

1. A compound of the formula (I) in which A represents CH, R1 represents a substituent chosen from the series consisting of (C1-C6)-alkyl, substituted by a group of the formula —NH—C(═O)—R5, wherein
R5 denotes (C1-C6)-alkyl, substituted by pyrazolyl,
wherein the pyrazolyl can be substituted once to three times in an identical or different manner by halogen, cyano, (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, trifluoromethyl or trifluoromethoxy, R2 represents a substituent chosen from the series consisting of halogen, cyano, nitro, (C1-C6)-alkyl, trifluoromethyl, hydroxyl, (C1-C6)-alkoxy, trifluoromethoxy, amino, hydroxycarbonyl and —C(═O)—NH—R8, wherein
(C1-C6)-alkyl and (C1-C6)-alkoxy in their turn can be substituted by hydroxylandR8 denotes hydrogen or (C1-C4)-alkyl, m represents the number 0, 1 or 2, n represents the number 0, 1, 2 or 3,
wherein, in the case where R1 or R2 occur several times, their meanings can in each case be identical or different, and R3 represents hydrogen, (C1-C6)-alkyl or (C3-C7)-cycloalkyl, or a salt thereof.