Processes employing cyclodextrin derivative quaternary salts

摘要

Chiral salts comprising anionic cyclodextrin derivatives with particular types of non-metal cations are provided. The anionic CD derivative salts can serve as ionic liquids and can possess substantial advantages over currently commercially available ionic liquids particularly for use as chiral phase transfer catalyst, chiral reaction medium, chiral extraction medium, and/or as chiral additive to a chemical process. Methods of preparing the same are provided.

主权项

1. An extraction process for the separation of enantiomers or diastereomers, the process comprising:
a. exposing a solid or liquid containing at least one compound to be extracted to an extraction phase containing a cyclodextrin derivative salt comprising one or more anionic cyclodextrin derivatives and one or more cations independently selected at each occurrence from a phosphonium cation or a quaternary nitrogen-containing cation, wherein the at least one compound is a mixture of Isomer-1 and Isomer-2 of enantiomers or diastereomers, and the salt comprises an anionic cyclodextrin derivative and a quaternary nitrogen-containing cation; b. mixing the solid or liquid with the extraction phase for a period of time sufficient to specifically or selectively extract a first portion of Isomer-1 into the extraction phase; and c. separating the extraction phase from the solid or liquid; and d. separating the extracted first portion of Isomer-1 from the extraction phase to provide an enantiomerically enriched, enantiomerically pure, diastereomerically-enriched or diastereomerically-pure Isomer-1 of the compound.