Preparation of organic compounds for enhanced reactivity

摘要

The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension.

主权项

1. A method of forming a precipitate, comprising the following steps:
(a) dissolving a starting form of a subject compound into an aqueous solvent to form an aqueous solution; and (b) adding a precipitating solvent to the aqueous solution to form a precipitate of the subject compound, wherein step (b) is performed after step (a), wherein the precipitating solvent is miscible in the aqueous solvent, and wherein the precipitate of the subject compound has a surface area per unit of mass that is greater than the surface area per unit of mass of the starting form of the subject compound; and wherein the subject compound is levo-thyroxine (T4), 3,5,3′-triiodo-L-thyronine (T3), or L-DOPA.