| 发明名称 | Intestinal barrier integrity | ||
| 摘要 | The invention concerns a method for stimulating barrier integrity in a mammal by administering to a mammal a composition comprising: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), and at least two distinct oligosaccharides. | ||
| 申请公布号 | US9084433(B2) | 申请公布日期 | 2015.07.21 |
| 申请号 | US201213594147 | 申请日期 | 2012.08.24 |
| 申请人 | N. V. Nutricia | 发明人 | Van Tol Eric Alexander Franciscus;Willemsen Linette Eustachia Maria;Koetsier Marleen Antoinette;Beermann Christopher;Stahl Bernd |
| 分类号 | A61K31/733;A61P1/00;A61P1/12;A61P37/08;A23L1/29;A23L1/30 | 主分类号 | A61K31/733 |
| 代理机构 | Foley & Lardner LLP | 代理人 | Villacorta Gilberto M.;Talapatra Sunit;Foley & Lardner LLP |
| 主权项 | 1. A method for stimulating intestinal barrier integrity, comprising administering to a mammal an infant formula nutritional composition comprising proteins, carbohydrates, and fats, the fats comprising: a. arachidonic acid (ARA), and optionally eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA), wherein the content of long chain polyunsaturated fatty acid with 20 and 22 carbon atoms is between 0.5-5 wt. % of the total fat content; and the carbohydrates comprising: b. at least two distinct oligosaccharides with a degree of polymerisation (DP) between 2 and 60 comprising galactooligosaccharide and a fructan selected from the group consisting of fructooligosaccharides, inulin and mixtures thereof, wherein the content of oligosaccharides is between 1-5 wt. %, based on total weight of a dry composition. | ||
| 地址 | Zoetermeer NL | ||