TISSUE-SPECIFIC BIOMARKERS OF AGEING

摘要

FIELD: medicine.SUBSTANCE: invention relates to field of biochemistry, in particular to method of identifying changes in gene expression, characteristic of ageing, in selected tissue. Selected tissue represents cardiac, muscular, cerebral or adipose tissue. Method includes selection of one or several genes, differentially expressed in tissue of old subjects in comparison with young subjects, with application of two criteria. Said criteria are: change of expression in at least 50% of lines, breeds or ethnic groups of tested species at preliminarily determined significance level p<0.10, as well as at least partial reversion of changes in gene expression by restriction in caloric content.EFFECT: invention provides obtaining reliable tissue-specific biomarkers of ageing.7 cl, 11 tbl, 5 ex