COMPOSTIONS AND METHODS FOR CANCER IMMUNOTHERAPY

摘要

The present invention provides a combination therapy which relies on a small molecule immune stimulator cyclic di nucleotide (CDN) that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes) formulated with allogeneic human tumor cell lines engineered to secrete high amounts of GM CSF. This combination therapy can provide an ideal synergy of multiple tumor associated antigens DC recruitment and proliferation coupled with a potent DC activation stimulus.