发明名称 |
ANTIBODY-DRUG CONJUGATE. |
摘要 |
Provided is an antibody-drug conjugate which can be used as an anti-tumor agent that has an excellent anti-tumor effect and is highly safe, said conjugate being characterized by being produced by binding an anti-tumor compound represented by formula (1) to an antibody through a linker having a structure represented by the formula: -L1-L2-LP-NH-(CH2)n 1-La-Lb-Lc- (wherein the antibody is bound at the terminal of L1, and the anti-tumor compound is bound at the terminal of Lc in which the binding site of the anti-tumor compound is a nitrogen atom in an amino group located at position-1). |
申请公布号 |
MX2015003903(A) |
申请公布日期 |
2015.07.17 |
申请号 |
MX20150003903 |
申请日期 |
2013.10.10 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
MASAO YOSHIDA;TAKESHI MASUDA;HIROYUKI NAITO;TAKASHI NAKADA;DAIICHI SANKYO;HIDEKI MIYAZAKI;YUJI KASUYA;KOJI MORITA;YUKI ABE;YUSUKE OGITANI |
分类号 |
C07K16/28;A61K31/4745;A61K31/48;A61K39/395;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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