METHODS FOR TREATING CARDIOVASCULAR DISEASES

摘要

The present invention is based in part on the discovery that an inhibitor of the 5-lipoxygenase pathway (for example, a 5-lipoxygenase inhibitor or a 5-lipoxygenaseactivating protein (FLAP) inhibitor) can preserve and improve cardiac function, mitigate cardiac dysfunction, as well as reduce epicardial adipose tissue and/or pericardial adipose tissue in a subject suffering from a cardiovascular disease. Accordingly, the present invention provides methods for mitigating cardiac dysfunction in a subject in need thereof by administering to the subject a composition comprising a 5-lipoxygenase inhibitor or a FLAP inhibitor. The present invention further provides methods for preserving and/or improving cardiac function in a subject in need thereof by administering to the subject a composition comprising a 5-lipoxygenase inhibitor or a FLAP inhibitor. In addition, the present invention provides methods for reducing epicardial adipose tissue and/or pericardial adipose tissue in a subject in need thereof by administering to the subject a composition comprising a 5-lipoxygenase inhibitor or a FLAP inhibitor.