FUNCTIONALIZED SUBSTRATES AND METHODS OF MAKING SAME

摘要

Polymer substrates including adhesion layers for activating the surface of the substrate are provided, thereby allowing the substrate to react with organic, inorganic, metallic and/or organometallic materials. The surface of the polymer substrate is coated with a metal oxide layer that is subjected to conditions adequate to form an oxide adhesion layer. Combining deposition techniques for formation of functionalized polymer surfaces with photolithographic techniques enables spatial control of RGD presentation at the polymer surfaces are achieved with sub-cellular resolution. Surface patterning enables control of cell adhesion location at the surface of the polymer and influences cell shape. Metallization of polymers as described herein provides a means to prepare metal-based electrical circuitry on a variety of flexible substrates.

主权项

1. A composition comprising a polymer substrate having a surface comprising a donor-electron pair on the surface capable of coordinating with a metal alkoxide, and a continuous oxide adhesion layer formed by a matrix of individual molecules that are chemically bonded and linked to each other, wherein the continuous oxide adhesion layer comprises a metal oxide bonded directly adjacent to the surface by vapor deposition or immersion deposition, and wherein the continuous oxide adhesion layer comprises a metal alkoxide, the metal alkoxide having been subjected to treatment by one or more of the group consisting of pyrolysis, microwaving, complete hydrolysis and partial hydrolysis.