| 摘要 |
PROBLEM TO BE SOLVED: To provide Treprostinil formulations which affects vasodilation, and increases the efficacy at lower doses due to the sustained presence of drugs at the site of action in the deep lung which contributes to lowering blood pressure.SOLUTION: By administration of aerosolized Treprostinil formulation containing Treprostinil Na represented by the following formula, the pulmonary deposition of Treprostinil can be made more homogeneously, and thereby, the deep lung delivery is enabled. The aerosolized formulation has an aerodynamic diameter of particles or droplets of 10 microns or less, and the administration results in depositing the Treprostinil in a deep lung, such that a ratio of central/peripheral lung deposits of the formulation is in a range of 1 to 2.0. |
